Promethazine Hydrochloride
Promethazine hydrochloride is a first-generation antihistamine and phenothiazine derivative containing a modified aromatic pyrimidine-like structure, primarily used to treat motion sickness, nausea, and allergic reactions. It falls under HTS 2933.59.21.00 as an aromatic antihistamine principally used as an anti-nauseant, consistent with chapter notes for heterocyclic nitrogen compounds with pyrimidine rings. This chemically defined compound is imported in pure form for pharmaceutical formulation.
Import Duty Rates by Country of Origin
Alternative Classifications
This product could be classified differently depending on its characteristics or intended use.
If lacking pyrimidine or piperazine ring but still aromatic drug
Heterocyclic drugs without specific pyrimidine/piperazine classify under 'other' aromatic drugs in 2933.39, per numerical order rule in chapter notes.
If imported as finished dosage form like tablets or syrup
Fully formulated medicaments with antihistamines move to Chapter 30 as finished drugs, not bulk chemicals.
If classified primarily as nucleic acid derivative
Certain modified aromatic heterocyclics with nucleotide function fall under 2934 per chapter exclusion notes prioritizing heteroatom rings.
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Import Tips & Compliance
• Verify USP-grade purity and provide FDA Drug Master File; ensure COA confirms aromatic structure and antihistamine potency
• Common pitfall: mislabeling as general chemical vs drug triggers reclassification
• Obtain prior FDA import alert clearance for bulk APIs
Related Products under HTS 2933.59.21.00
Cyclizine Hydrochloride
Cyclizine hydrochloride is a piperazine-based antihistamine used mainly for preventing motion sickness and treating vertigo/nausea. Its heterocyclic structure with piperazine ring qualifies it under HTS 2933.59.21.00 as an aromatic antihistamine anti-nauseant. Chapter notes confirm classification for separate chemically defined compounds with nitrogen hetero-atoms.
Buclizine Hydrochloride
Buclizine hydrochloride, a piperazine antihistamine, treats nausea, vomiting, and motion sickness with antiemetic properties. Classified under HTS 2933.59.21.00 for its aromatic heterocyclic structure containing piperazine ring, as a drug principally used as anti-nauseant. Meets chapter definition for separate organic compounds with nitrogen hetero-atoms.
Meclizine Hydrochloride
Meclizine hydrochloride is a piperazine antihistamine primarily indicated for motion sickness prevention and vertigo treatment. Its modified aromatic structure with piperazine qualifies for HTS 2933.59.21.00 as an anti-nauseant drug. Chapter notes support classification of such chemically defined pharmaceuticals.
Dimenhydrinate
Dimenhydrinate is the aminophylline salt of diphenhydramine, functioning as an antihistamine antiemetic for motion sickness. Despite salt form, classified with the organic base under HTS 2933.59.21.00 per chapter note C(1) for aromatic pyrimidine-related antihistamines. Used principally as anti-nauseant.
Hydroxyzine Hydrochloride
Hydroxyzine hydrochloride, a piperazine antihistamine, treats anxiety, itching, and nausea pre-surgery. Falls under HTS 2933.59.21.00 for aromatic heterocyclic drugs principally used as antihistamines/anti-nauseants. Chemically defined per chapter (a) with stabilizer allowances.
Chlorpheniramine Maleate
Chlorpheniramine maleate is an alkylamine antihistamine with modified aromatic structure used for allergies and sometimes nausea. Imported under HTS 2933.59.21.00 as it qualifies among aromatic antihistamines per subheading scope. Chapter notes allow salt classification with acid/base.