Somatrem (Methionyl Human Growth Hormone)
Somatrem is a structurally modified form of human somatotropin with an extra methionine residue at the N-terminus, making it a derivative used for growth hormone replacement therapy. This analogue maintains the biological activity of natural somatotropin. Falls under HTS 2937.11.00.00 due to its classification as a somatotropin derivative used primarily as a hormone.
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Alternative Classifications
This product could be classified differently depending on its characteristics or intended use.
If in vaccine or toxin preparations containing growth hormone derivatives
Immunological products including hormones as active components are classified in 3002.
If for other polypeptide hormones not specifically somatotropin
Different polypeptide hormones have separate subheadings within 2937.1.
If when imported temporarily for research or clinical trials
Articles imported for scientific research may qualify for duty-free entry under special provisions.
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Import Tips & Compliance
• Include structural characterization documents showing the methionine modification to confirm derivative status
• Ensure cold chain documentation for biologics stability during transport
• Declare as 'hormone for therapeutic use' to prevent classification as research chemical
Related Products under HTS 2937.11.00.00
Recombinant Human Growth Hormone (Somatropin)
Somatropin is a recombinant DNA-derived version of human somatotropin (growth hormone), identical in structure to the natural pituitary hormone. It is used primarily to treat growth hormone deficiency in children and adults. Classified under HTS 2937.11.00.00 as a structural analogue of somatotropin used primarily as a hormone.
Somatrogon (Long-Acting Growth Hormone)
Somatrogon is a long-acting structural analogue of somatotropin created by linking human growth hormone to a CTP (C-terminal peptide) sequence from hCG beta subunit. This modification extends its half-life for weekly dosing in growth hormone deficiency. Classified in HTS 2937.11.00.00 as a chain-modified polypeptide analogue used primarily as a hormone.
Pegylated Somatotropin (PEG-GH)
Pegylated growth hormone is human somatotropin conjugated with polyethylene glycol (PEG) to extend its circulating half-life and reduce injection frequency. This structural modification creates a derivative used primarily for growth hormone therapy. HTS 2937.11.00.00 applies to such chain-modified polypeptide hormone analogues.
Mecasermin (Recombinant IGF-1)
Mecasermin is recombinant insulin-like growth factor 1 (IGF-1), a structural analogue closely related to the somatotropin/IGF-1 axis used in severe primary IGF-1 deficiency. While IGF-1 mediates somatotropin effects, its classification follows chapter notes for hormone analogues. HTS 2937.11.00.00 includes such polypeptide hormones used primarily in growth regulation.
Somatotropin Lyophilized Powder for Injection
Lyophilized (freeze-dried) powder form of recombinant human somatotropin for reconstitution prior to injection, used in growth hormone replacement therapy. This presentation maintains the structural integrity of the polypeptide hormone. Classified under HTS 2937.11.00.00 as bulk somatotropin derivative for pharmaceutical use.
Human Growth Hormone Reference Standard USP
USP reference standard of recombinant somatotropin used for quality control, assay calibration, and standardization in pharmaceutical manufacturing of growth hormone products. Meets pharmacopeial specifications for identity, potency, and purity. Classified under HTS 2937.11.00.00 as authentic somatotropin used in hormone-related applications.