Methotrexate from Japan
Methotrexate is a folic acid antagonist containing pteridine heterocyclic rings, used as an antineoplastic and immunosuppressant drug. Classified under HTS 2934.99.4700 as a pharmaceutical drug with 'other heterocyclic compounds' structure. Its complex ring system with multiple nitrogens defines its Chapter 29 placement.
Duty Rate — Japan → United States
23.8%
Rate breakdown
9903.04.6211.3%Patented pharmaceutical articles that are the product of Japan, of a European Union member country, of South Korea, of Switzerland, or of Liechtenstein as provided for in subdivisions (c) and (f) of U.S. note 40 to this subchapter
9903.05.4912.5%Except for products described in headings 9903.05.85–9903.05.92, articles the product of Japan, with an ad valorem (or ad valorem equivalent) rate of duty under column 1 less than 12.5 percent, as provided for in U.S. note 52 to this subchapter
Import Tips
• Submit FDA IND/NDA documentation for API import; maintain GMP-certified supply chain; beware reclassification risk if purity <99% suggesting intermediate status