Methotrexate
Methotrexate is a folic acid antagonist containing pteridine heterocyclic rings, used as an antineoplastic and immunosuppressant drug. Classified under HTS 2934.99.4700 as a pharmaceutical drug with 'other heterocyclic compounds' structure. Its complex ring system with multiple nitrogens defines its Chapter 29 placement.
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Alternative Classifications
This product could be classified differently depending on its characteristics or intended use.
If imported as synthetic organic dye intermediate
Pteridine derivatives without specific drug function classify under 2933
If when imported as finished tablet/capsule dosage form
Completed medicaments transfer to Chapter 30 regardless of chemical structure
If classified by carboxamide function over heterocycle
Chapter notes prioritize oxygen/nitrogen functions in some cases over ring structure
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Import Tips & Compliance
• Submit FDA IND/NDA documentation for API import; maintain GMP-certified supply chain; beware reclassification risk if purity <99% suggesting intermediate status
Related Products under HTS 2934.99.47.00
Adenosine Triphosphate (ATP) Sodium Salt
ATP sodium salt is a chemically defined nucleic acid derivative used as a pharmaceutical drug in biochemical research and medical treatments for energy metabolism disorders. It falls under HTS 2934.99.4700 as a nucleic acid salt classified as a drug, containing a heterocyclic purine base structure. This pure compound meets Chapter 29 requirements for separate chemically defined organic compounds.
5-Fluorouracil
5-Fluorouracil is a fluorinated pyrimidine analog used as an antineoplastic drug for cancer chemotherapy. This chemically defined heterocyclic compound with nitrogen heteroatoms qualifies under HTS 2934.99.4700 as 'other heterocyclic drugs.' Its pharmaceutical drug status distinguishes it from industrial chemicals.
Caffeine Anhydrous USP
Pharmaceutical grade caffeine anhydrous is a purine alkaloid (xanthine derivative) used in medications for respiratory stimulation and pain relief. This purine heterocyclic compound classifies under HTS 2934.99.4700 as a drug, distinct from food-grade or beverage use. Meets Chapter 29 criteria for chemically defined compounds.
Theophylline
Theophylline is a methylxanthine bronchodilator drug containing fused purine heterocyclic rings, used for asthma treatment. Falls under HTS 2934.99.4700 as a 'drug' heterocyclic compound per its pharmaceutical application and chemical definition. Excluded from earlier alkaloid headings due to specific drug status.
Allopurinol
Allopurinol is a hypoxanthine analog (purine heterocycle) used to treat gout by inhibiting xanthine oxidase. This chemically defined drug compound is properly classified under HTS 2934.99.4700 for other heterocyclic drugs. Its pharmaceutical purity distinguishes it from research chemicals.
Colchicine USP
Colchicine USP is an alkaloid drug containing a tropolone ring system (seven-membered heterocycle with oxygen), used for gout and Mediterranean fever. Classified as HTS 2934.99.4700 drug due to its complex heterocyclic structure and pharmaceutical use. Excluded from Chapter 29 alkaloid headings.