Ivabradine Hydrochloride from Japan
Ivabradine hydrochloride selectively inhibits funny current (If) in sinoatrial node for heart rate reduction in chronic heart failure. Nitrogen-heterocyclic aromatic compound under HTS 2933.99.53.00. Bulk API as crystalline HCl salt.
Duty Rate — Japan → United States
15%
Rate breakdown
9903.04.628.5%Patented pharmaceutical articles that are the product of Japan, of a European Union member country, of South Korea, of Switzerland, or of Liechtenstein as provided for in subdivisions (c) and (f) of U.S. note 40 to this subchapter
9903.05.900%Articles of aluminum, of steel or of copper or derivative aluminum or steel articles; passenger vehicles (sedans, sport utility vehicles, crossover utility vehicles, minivans and cargo vans) and light trucks; parts of passenger vehicles (sedans, sport utility vehicles, crossover utility vehicles, minivans and cargo vans) and light trucks; medium- and heavy-duty vehicles; parts of medium- and heavy-duty vehicles; wood products; patented pharmaceutical articles; and semiconductor articles, as provided in subdivision (f) of U.S. note 52 to this subchapter
Import Tips
• Phosphenes (visual effects) class effect - include ophthalmology data
• CYP3A4 substrate - extensive DDI studies required
• Highly potent - 5-7.5mg doses require content uniformity focus