Celecoxib API
Celecoxib is a selective COX-2 inhibitor used as the active pharmaceutical ingredient in anti-inflammatory drugs like Celebrex for treating arthritis. It contains an unfused pyrazole ring in its heterocyclic structure, qualifying it under HTS 2933.19.4500 as a pyrazole-based drug. This classification applies to pure chemical compounds intended for pharmaceutical use.
Import Duty Rates by Country of Origin
Alternative Classifications
This product could be classified differently depending on its characteristics or intended use.
If containing a different unfused azole ring like 1,2,4-triazole
Pyrazole-specific subheading 2933.19 applies only to unfused pyrazole rings; triazole derivatives shift to 2933.59
If imported as formulated tablets or capsules rather than pure API
Finished pharmaceutical products fall under Chapter 30; bulk chemical APIs remain in Chapter 29
If for veterinary use rather than human drugs
Subheading .4500 specifies human drugs; veterinary pyrazole compounds classify under other .99 provisions
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Import Tips & Compliance
• Obtain FDA Drug Master File (DMF) and ensure API meets cGMP standards with full impurity profile documentation
• Provide Certificate of Analysis (CoA) confirming pyrazole structure and pharmacological purity above 99%
• Avoid misclassification as finished dosage forms; declare as bulk API to prevent higher Chapter 30 duties
Related Products under HTS 2933.19.45.00
Rizatriptan Benzoate API
Rizatriptan benzoate is the active ingredient in Maxalt for migraine treatment, featuring a pyrazole ring in its structure. Classified under HTS 2933.19.4500 as a drug containing unfused pyrazole ring per Chapter 29 notes. Used primarily as a serotonin receptor agonist in pharmaceutical manufacturing.
Fomepizole API
Fomepizole is an antidote for ethylene glycol/methanol poisoning, featuring a simple 4-methylpyrazole structure. Classified under HTS 2933.19.4500 as a pyrazole ring drug for emergency medical use. Provided as sterile injectable-grade API.
Aminaphtone API
Aminaphtone is a pyrazole derivative used for capillary fragility treatment in vascular disorders. Features 4-amino-3-methyl-1-phenylpyrazol-5-one structure qualifying under HTS 2933.19.4500. Pharmaceutical grade for tablet manufacturing.
Metamizole Sodium API
Metamizole sodium (dipyrone) contains pyrazole ring as analgesic/antipyretic active ingredient. Classifies under HTS 2933.19.4500 as pyrazole drug despite sodium salt form per Chapter note 5(C). Used globally for pain relief.
Sildenafil Citrate API
Sildenafil citrate, the active ingredient in Viagra, contains a pyrazole ring within its heterocyclic structure for erectile dysfunction treatment. Falls under HTS 2933.19.4500 as a pyrazole-containing drug per Chapter 29 chemical classification rules. Supplied as bulk powder for tablet formulation.
Zaleplon API
Zaleplon, active in Sonata sleep aid, contains pyrazole ring as core structure for non-benzodiazepine hypnotic action. HTS 2933.19.4500 classification for unfused pyrazole drugs. Bulk API for capsule production.